Neuroimaging and Interventional Radiology

Biography

Biography: Bob L Hou

Abstract

We hypothesized that tumor cells’ infiltration and vasculatures in the adjacent primary sensory motor cortex (PSMC) are two main factors for diminishing BOLD signal (SI) in the PSMC or changing functional connectivity (FC) in the sensory and motor network (SMN) of patients with glioblastoma multiforme (GBM), and the effects on the signal or on the FC are different. The t-test results (i.e., the P values) on 10 patients with GBMs suggest there are statistical differences for the SI, FCs and rCBF in the two brain hemispheres: SI and FC will be diminished, and the rCBF will be increased. The R2 of the fitting results demonstrated that the distance of the tumor edges to PSMCs: a surrogate indicator of the tumor cells’ penetration is positively linear correlated the SI, but the R2 for the distance of the tumor edges to SMNs VS the FCs suggested no correlation between tumor cell’s infiltration and the FCs. The R2 suggests the distance of tumor vasculatures, which is an index of neural-vasculature decoupling (NVD) and neural blood stealing factor, to PSMCs or SMN plays more important role for diminishing the SI and FC due to the exponential decreasing trends for both. The R2 for the rCBF ratios VS the SI ratios exposes a negative linear relation, and the R2 demonstrates no correlation between the rCBF ratios and the FC ratios. The SI’s reducing is linked to the tumor and rCBF distances and its value, and the FC’s reduction is only associated to the rCBF distance.