Dnyanesh N. Tipre
United Translational Molecular Imaging Center, India
Title: Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging
Biography
Biography: Dnyanesh N. Tipre
Abstract
Various teams of scientists have contributed their efforts in assessing the metabotropic glutamate receptor 5 (mGluR5) as a biomarker in neuropsychiatric disorders and diseases. Development of positive and negative allosteric modulators of mGluR5 and PET radioligands that have the potential to measure mGluR5 receptor density in neurological disorders and during therapeutic interventions have been investigated. PET imaging provides an effective tool to assess the specificity of new drugs, select dose regimens in clinical trials, and study drug mechanisms of action. This presentation will deliver comparative analyses of mGluR5-specific PET radiotracers and their applications in understanding the pathophysiology of mGluR5-related nervous system disorders and to speed up drug development. Transcranial magnetic stimulation (TMS) is a magnetic method used to stimulate small regions of the brain. Evidence suggests it is useful for neuropathic pain and treatment-resistant major depressive disorder (MDD). The presentation will cover application of TMS in MDD with or without drug treatment. The presentation will also highlight potential applications of multi-imaging modalities such PET/MRS to measure functional changes in the brain before and after treatment.