Rong Fu Wang
Peking University Health Science Center, Chinia
Title: Study in vivo on Neuroreceptor and Neurotransmitter Imaging with Radionuclide Tracing
Biography
Biography: Rong Fu Wang
Abstract
Neuroreceptor and neurotransmitter imaging is a new developed domain in the study of nervous nuclear medicine in the 21st century. Recently in the biological area, the exploration of receptor function and its biological characteristics in molecular medical level and the diagnosis and management of receptor disorders are an advanced domain of international medical science investigation. The neuroreceptor and neurotransmitter imaging in vivo using radioligand is a new molecular medicine of medical tracing technique combined with molecular biology and nuclear medicine, i.e. the molecular nuclear medicine will be a new means applied for detecting functional brain abnormalities in nuclear neurology rn Neuroreceptor and neurotransmitter imaging with radionuclide tracing in vivo have been greatly developed recently. Distribution, density, and activity of receptors in the brain can be visualized by the radioligands labeled for emission computed tomography(ECT), including PET(positron emission tomography) and SPECT(single photon emission computed tomography). The continual emergence of new positron radiopharmaceuticals, especial positron neuroreceptor and neurotransmitter imaging agents, further promotes and extends the clinical applications of PET, PET/CT and PET/MR. The researches on PET, PET/CT and PET/MR have become an attractive area now. The functional and quantitative imaging for several receptors, such as dopamine receptors and dopamine neurotransmitter, serotonin receptors, cholinergic receptors, benzodiazepine receptors, and opioid receptors, have clinical importance. The preparation of neuroreceptor and neurotransmitter imaging agent, foundation of physio-mathematical model, and the development of nuclear medicine instrument are the main points. In present review, we will concentrate on introducing the development of neuro receptor and neurotransmitter imaging.